What is YESCARTA?

YESCARTA is a treatment for your non-Hodgkin lymphoma. It is used when you have failed at least 2 other kinds of treatment. This type of treatment is known as Chimeric Antigen Receptor T-cell (CAR T) therapy. Discuss YESCARTA therapy with your doctor to see if it might be right for you.

How YESCARTA is different

Personalized Immunotherapy

YESCARTA is different than most other cancer medicines because it is made from your own white blood cells (T cells), which have been modified to recognize and attack your lymphoma cells.

Your T cells are a kind of white blood cell that has the job of targeting and destroying bacteria, viruses, and cancer cells. However, with certain types of B-cell cancers, your T cells may not be able to do their job properly.

That’s where a CAR T therapy like YESCARTA may help.

Immunotherapy Icon

How YESCARTA Works

Process of collecting and modifying t-cells from human body
Your T cells are collected

First, your blood is collected and passed through a machine that separates out some of your T cells. This is called leukapheresis (loo-kah-fur-ee-sis), a process that can take 3-4 hours.

T cells are modified

After your T cells are collected, they are sent to a laboratory and modified to become CAR T cells.

Your CAR T cells are then infused
back into your body

Once infused, your modified CAR T cells can recognize and attack your lymphoma cells.

This process typically takes 3-4 weeks, but time may vary for each patient.

Results with YESCARTA

YESCARTA is a one-time therapy that offers a chance for complete remission

In a clinical study of 101 patients with non-Hodgkin lymphoma who had failed other treatments, YESCARTA was shown to help 51% (52 out of 101) achieve complete remission.

Rapid Response

People generally responded to treatment within 1 month (range: 0.8-6.2 months).

Ongoing Response

For those who achieved a complete remission, the response is generally ongoing.

Chart showing results of Yescarta therapy

Understanding the Risks


It’s typical to experience serious side effects after receiving YESCARTA. It’s very important to understand what to look for and notify your healthcare team should side effects occur. Side effects with YESCARTA are generally manageable.



What is the most important information
I should know about YESCARTA?

YESCARTA may cause side effects that are life-threatening and can lead to death. Call or see your healthcare provider or get emergency help right away if you get any of the following:

  • Fever (100.4°F/38°C or higher)
  • Difficulty breathing
  • Chills or shaking chills
  • Confusion
  • Dizziness or lightheadedness
  • Severe nausea, vomiting, or diarrhea
  • Fast or irregular heartbeat
  • Severe fatigue or weakness

It is important to tell your healthcare provider that you received YESCARTA and to show them your YESCARTA Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

What are the possible or reasonably likely
side effects of YESCARTA?

The most common side effects of YESCARTA include:

  • Fever (100.4°F/38°C or higher)
  • Low white blood cells (can occur with a fever)
  • Low red blood cells
  • Low blood pressure (dizziness or lightheadedness, headache, feeling tired, short of breath)
  • Fast heartbeat
  • Confusion
  • Difficulty speaking or slurred speech
  • Nausea
  • Diarrhea

These are not all the possible side effects of YESCARTA. Call your healthcare provider about any side effects that concern you.

Your healthcare team will monitor you for side effects during and after treatment with YESCARTA and may give you other medicines to treat your side effects. Receiving emergency medical attention right away may keep side effects from becoming more serious.

YESCARTA
Available at
Authorized Treatment Centers
Important Safety Information

What is the most important information I should know about YESCARTA?

YESCARTA may cause side effects that are life-threatening and can lead to death. Call or see your healthcare provider or get emergency help right away if you get any of the following:

  • Fever (100.4°F/38°C or higher)
  • Difficulty breathing
  • Chills or shaking chills
  • Confusion
  • Dizziness or lightheadedness
  • Severe nausea, vomiting, or diarrhea
  • Fast or irregular heartbeat
  • Severe fatigue or weakness

It is important to tell your healthcare provider that you received YESCARTA and to show them your YESCARTA Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

Before getting YESCARTA, tell your healthcare provider about all your medical problems, including if you have or have had:

  • Neurologic problems (such as seizures, stroke, or memory loss)
  • Lung or breathing problems
  • Heart problems
  • Liver problems
  • Kidney problems
  • A recent or active infection

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive YESCARTA?

  • Since YESCARTA is made from your own white blood cells, your blood will be collected by a process called “leukapheresis” (loo-kah-fur-ee-sis), which will concentrate your white blood cells.
  • Your blood cells will be sent to a manufacturing center to make your YESCARTA.
  • Before you get YESCARTA, you will get 3 days of chemotherapy to prepare your body.
  • When your YESCARTA is ready, your healthcare provider will give it to you through a catheter placed into your vein (intravenous infusion). The infusion usually takes less than 30 minutes.
  • You will be monitored where you received your treatment daily for at least 7 days after the infusion.
  • You should plan to stay close to the location where you received your treatment for at least 4 weeks after getting YESCARTA. Your healthcare provider will help you with any side effects that may occur.
  • You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
  • Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

What should I avoid after receiving YESCARTA?

  • Do not drive, operate heavy machinery, or do other dangerous things for 8 weeks after you get YESCARTA because the treatment can cause sleepiness, confusion, weakness, temporary memory and coordination problems.
  • Do not donate blood, organs, tissues, and cells for transplantation.

What are the possible or reasonably likely side effects of YESCARTA?

The most common side effects of YESCARTA include:

  • Fever (100.4°F/38°C or higher)
  • Low white blood cells (can occur with a fever)
  • Low red blood cells
  • Low blood pressure (dizziness or lightheadedness, headache, feeling tired, short of breath)
  • Fast heartbeat
  • Confusion
  • Difficulty speaking or slurred speech
  • Nausea
  • Diarrhea

These are not all the possible side effects of YESCARTA. Call your healthcare provider about any side effects that concern you. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including IMPORTANT WARNING and Medication Guide.

INDICATION

YESCARTA is a treatment for your non-Hodgkin lymphoma. It is used when you have failed at least two other kinds of treatment. YESCARTA is different than other cancer medicines because it is made from your own white blood cells, which have been modified to recognize and attack your lymphoma cells.

Limitation of Use: YESCARTA is not indicated for the treatment of patients with primary central nervous system lymphoma.