How Will I Receive Treatment?

YESCARTA is administered as a one-time infusion at an authorized treatment center. The entire treatment process consists of 6 distinct steps. Your healthcare team and support system are there to help you every step of the way, so it's important that you openly communicate with your healthcare team and ask questions.

Step 1:
Leukapheresis (loo-kah-fur-ee-sis)

Since YESCARTA is made from your own T cells, it requires your healthcare team to collect and separate T cells from your other blood cells. This collection process is called leukapheresis.

During this process, some of your blood will be collected intravenously (IV) and passed through a machine that separates your T cells from the other blood cells. Through the use of this specialized machine, the remaining blood is then returned into your body through the IV line. The leukapheresis process takes between 3 and 4 hours. Following the process, your collected T cells are then transported to the manufacturing facility to be engineered.

Step 2:
Cell Manufacturing

After collection, your T cells will be sent to a laboratory to be made into CAR T cells ( YESCARTA). These CAR T cells will then be returned to your healthcare provider to prepare your infusion.

Step 3:
Conditioning Chemotherapy

Before your single infusion of YESCARTA, you will undergo 3 days of low-dose conditioning chemotherapy to prepare your body for treatment.

Step 4:
Infusion

On the night before or the day of your scheduled infusion, you will go to the authorized treatment center with your caregiver. Your healthcare team will administer a single infusion of YESCARTA into your vein through a central IV line. The infusion should take about 30 minutes.

Step 5:
Monitoring

You will be monitored where you received your treatment daily for at least 7 days after your infusion. Plan to stay close, within 2 hours of the location where you received your treatment for at least 4 weeks. Your healthcare provider will monitor to see how your treatment is working and help you with any side effects that may occur.

You may be hospitalized for side effects. Your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.

Step 6:
Follow-up

You will have follow-up appointments to track your progress. Your healthcare team will check to see if your treatment is working, perform blood tests as necessary, and help you with any side effects that may occur.

If you miss any appointments, call your healthcare team as soon as possible to reschedule your appointment.

YESCARTA
Available at
Authorized Treatment Centers
Important Safety Information

What is the most important information I should know about YESCARTA?

YESCARTA may cause side effects that are life-threatening and can lead to death. Call or see your healthcare provider or get emergency help right away if you get any of the following:

  • Fever (100.4°F/38°C or higher)
  • Difficulty breathing
  • Chills or shaking chills
  • Confusion
  • Dizziness or lightheadedness
  • Severe nausea, vomiting, or diarrhea
  • Fast or irregular heartbeat
  • Severe fatigue or weakness

It is important to tell your healthcare provider that you received YESCARTA and to show them your YESCARTA Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

Before getting YESCARTA, tell your healthcare provider about all your medical problems, including if you have or have had:

  • Neurologic problems (such as seizures, stroke, or memory loss)
  • Lung or breathing problems
  • Heart problems
  • Liver problems
  • Kidney problems
  • A recent or active infection

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive YESCARTA?

  • Since YESCARTA is made from your own white blood cells, your blood will be collected by a process called “leukapheresis” (loo-kah-fur-ee-sis), which will concentrate your white blood cells.
  • Your blood cells will be sent to a manufacturing center to make your YESCARTA.
  • Before you get YESCARTA, you will get 3 days of chemotherapy to prepare your body.
  • When your YESCARTA is ready, your healthcare provider will give it to you through a catheter placed into your vein (intravenous infusion). The infusion usually takes less than 30 minutes.
  • You will be monitored where you received your treatment daily for at least 7 days after the infusion.
  • You should plan to stay close to the location where you received your treatment for at least 4 weeks after getting YESCARTA. Your healthcare provider will help you with any side effects that may occur.
  • You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
  • Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

What should I avoid after receiving YESCARTA?

  • Do not drive, operate heavy machinery, or do other dangerous things for 8 weeks after you get YESCARTA because the treatment can cause sleepiness, confusion, weakness, temporary memory and coordination problems.
  • Do not donate blood, organs, tissues, and cells for transplantation.

What are the possible or reasonably likely side effects of YESCARTA?

The most common side effects of YESCARTA include:

  • Fever (100.4°F/38°C or higher)
  • Low white blood cells (can occur with a fever)
  • Low red blood cells
  • Low blood pressure (dizziness or lightheadedness, headache, feeling tired, short of breath)
  • Fast heartbeat
  • Confusion
  • Difficulty speaking or slurred speech
  • Nausea
  • Diarrhea

These are not all the possible side effects of YESCARTA. Call your healthcare provider about any side effects that concern you. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including IMPORTANT WARNING and Medication Guide.

INDICATION

YESCARTA is a treatment for your non-Hodgkin lymphoma. It is used when you have failed at least two other kinds of treatment. YESCARTA is different than other cancer medicines because it is made from your own white blood cells, which have been modified to recognize and attack your lymphoma cells.

Limitation of Use: YESCARTA is not indicated for the treatment of patients with primary central nervous system lymphoma.