But in some B-cell lymphomas, your T cells cannot recognize
the
cancer cells, which can allow the cancer cells to grow.
To make your CAR T cells, your own T cells are collected from
your blood and sent to the manufacturing facility.
There, your T cells are modified to have
Chimeric Antigen Receptors (CARs)?. This turns them into CAR T cells. This is a careful process that usually takes at least 2–3 weeks and has many quality checks.
On the day of your YESCARTA treatment, you receive millions
of
CAR T cells by infusion.
Once in your body, your new CAR T cells can now recognize certain blood cancer cells and attack them.
After receiving YESCARTA, you will stay at the
certified treatment center?, where the treatment team will monitor and manage any side effects.
“I didn't know anything about CAR T at first, and it is still something I struggle to explain in an eloquent way. It's a treatment that I am forever grateful I had access to.”
LayraYESCARTA Patient
This testimonial is representative of the patient’s own experience.
Individual treatment results and experience may vary.
This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.
What’s important to know when considering YESCARTA?
Here are three special considerations that may be different from your experience with other cancer treatments. There may be other considerations depending on your situation. Ask your oncologist or treatment team for more information.
YESCARTA is only given at certified treatment centers?, also known as authorized treatment centers. These centers have medical staff who are specifically trained to take care of you throughout the whole CAR T-cell therapy process.
You can expect to stay at the certified treatment center for at least 1 week after infusion, and have multiple appointments before and after. Visit the
Receiving YESCARTA page to learn more.
Your treatment team will let you know how close you need to stay to a certified healthcare facility for the first 4 weeks after infusion. If you don’t live nearby, you may need to travel, find lodging, and consider other costs.
Find and learn about a certified treatment center close to you:
YESCARTA may cause side effects that are life-threatening and can lead to death. Your treatment team at the certified treatment center will be working with you to closely monitor and manage side effects.
Some side effect symptoms can be hard for patients to recognize, and this is one of the reasons you will need a dedicated caregiver. If you don’t have a dedicated caregiver, you can work with your treatment team to come up with a solution.
Each step of treatment can take time to organize and prepare for. Talk to your treatment team about planning for CAR T.
“I read as much as I could, and listening to other patients’ stories was so valuable. Even though I was afraid, I knew I could do it. I was only the 13th person to have treatment after FDA approval.”
NikkiYESCARTA Patient
This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.
This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.
CAR T-cell therapy, or CAR T for short, is a type of immunotherapy. In CAR T, your T cells are modified to recognize and attack certain cancer cells. This is done by modifying your T cells to have Chimeric Antigen
Receptors (CARs). This turns them from T cells into CAR T cells.
A Chimeric Antigen Receptor (CAR) is a special molecule designed to help T cells recognize and attack cancer cells.
CARs hook onto a specific marker that cancer cells have a lot of. These markers are called antigens. When CARs hook onto these antigens, it can cause T cells to respond.
With YESCARTA, the CARs hook onto CD19, which is found on cancerous and normal B cells.
Patient and caregiver perspectives
This testimonial is representative of patients’ and caregivers’ own experiences.
Individual treatment results and experience may vary.
What to know about CAR T
Learn about what was important to other patients and caregivers
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Certified treatment center locator tool
There are over 150 cancer centers certified to provide YESCARTA throughout the US. When choosing a location, consider that you will need to stay close to a center for at least 4 weeks after receiving YESCARTA.
You can use the locator tool to find and learn about nearby treatment centers and their teams.
Information on new centers (where available) will be added on an ongoing basis. You can also contact your treatment team to learn more.
Traveling From
Typical driving times around your location
1 hour2 hours
Certified treatment centers (also called Authorized Treatment Centers) are independent facilities certified to dispense Kite CAR T therapies. Choice of a certified treatment center is within the sole discretion of the physician and patient. Kite does not endorse any individual treatment sites. Insurance coverage should be considered when reviewing certified treatment center options.
If you have questions at any step of the CAR T process, our dedicated team at Kite can help.
In order to provide YESCARTA, cancer treatment centers must first be certified. Certified treatment centers have specifically-trained medical staff, strict treatment protocols, and safety measures in place
for CAR T-cell therapy. These centers are often first to use best care practices learned through research.
Certified treatment centers are sometimes known as authorized treatment centers, or certified healthcare facilities.
Approved Uses
YESCARTA is a prescription medicine used to treat two types of non-Hodgkin
lymphoma ...
Important Safety Information
What is the most important information I should know about YESCARTA? YESCARTA may cause side effects that
are life-threatening and can lead to death ...
YESCARTA® is a prescription medicine used to treat two types of non-Hodgkin lymphoma:
large B-cell lymphoma when your first treatment did not work or your cancer returned within a year of first treatment, OR when at least two kinds of treatment have failed to control your cancer.
follicular lymphoma when at least two kinds of treatment have failed to control your cancer.
YESCARTA is different than other cancer medicines because it is made from your own white blood cells, which have been modified to recognize and attack your lymphoma cells.
Important Safety Information
What is the most important information I should know about YESCARTA?
YESCARTA may cause side effects that are life-threatening and can lead to death. Call or see your healthcare provider or get emergency help right away if you get any of the following:
Fever (100.4°F/38°C or higher)
Difficulty breathing
Chills or shaking chills
Confusion
Dizziness or lightheadedness
Severe nausea, vomiting, or diarrhea
Fast or irregular heartbeat
Severe fatigue or weakness
It is important to tell your healthcare provider that you received YESCARTA and to show them your YESCARTA Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side
effects.
Before getting YESCARTA, tell your healthcare provider about all your medical problems, including if you have or have had:
Neurologic problems (such as seizures, stroke, or memory loss)
Lung or breathing problems
Heart problems
Liver problems
Kidney problems
A recent or active infection
Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
How will I receive YESCARTA?
Since YESCARTA is made from your own white blood cells, your blood will be collected by a process called “leukapheresis” (loo-kah-fur-ee-sis), which will concentrate your white blood cells.
Your blood cells will be sent to a manufacturing center to make your YESCARTA.
Before you get YESCARTA, you will get 3 days of chemotherapy to prepare your body.
When your YESCARTA is ready, your healthcare provider will give it to you through a catheter placed into your vein (intravenous infusion). The infusion usually takes less than 30 minutes.
You will be monitored where you received your treatment daily for at least 7 days after the infusion.
You should plan to stay close to a certified healthcare facility for at least 4 weeks after getting YESCARTA. Your healthcare provider will help you with any side effects that may occur.
You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon
as possible to reschedule.
What should I avoid after receiving YESCARTA?
Do not drive, operate heavy machinery, or do other dangerous things for 8 weeks after you get YESCARTA because the treatment can cause sleepiness, confusion, weakness, and temporary memory and
coordination problems.
Do not donate blood, organs, tissues, or cells for transplantation.
What are the possible or reasonably likely side effects of YESCARTA?
The most common side effects of YESCARTA include:
Fever (100.4°F/38°C or higher)
Low white blood cells (can occur with a fever)
Low red blood cells
Low blood pressure (dizziness or lightheadedness, headache, feeling tired, short of breath)
Fast heartbeat
Confusion
Difficulty speaking or slurred speech
Nausea
Diarrhea
YESCARTA may increase your risk of getting cancers including certain types of blood cancers. Your healthcare provider should monitor you for this.
These are not all the possible side effects of YESCARTA. Call your healthcare provider about any side effects that concern you. You are encouraged to report negative side effects of prescription drugs
to the FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.
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