Who is YESCARTA for?

YESCARTA is used to treat two different types of non-Hodgkin lymphoma:

Large B-Cell Lymphoma (LBCL) in adults who have tried:

  • one previous treatment that didn't work, or
  • one previous treatment and had their cancer come back within 12 months, or
  • two or more previous treatments that didn't work, or
  • two or more previous treatments and had their cancer come back

Follicular Lymphoma (FL) in adults who have tried:

  • two or more previous treatments that didn't work, or
  • two or more previous treatments and had their cancer come back

Over 13,000 patients have been treated with YESCARTA*

Ask your doctor if YESCARTA is an option for you.

*As of May 31, 2023, this number includes global internal Kite commercial and clinical trial data


How does YESCARTA work?

YESCARTA is a type of CAR T-cell therapy?. CAR T is different from other cancer treatments because it is made from your own T cells.

What is CAR T-cell therapy?

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Flip through the story below to understand how YESCARTA helps your T cells recognize and attack certain blood cancers.

“I didn't know anything about CAR T at first, and it is still something I struggle to explain in an eloquent way. It's a treatment that I am forever grateful I had access to.”

LayraYESCARTA Patient

This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.

Layra YESCARTA® (axicabtagene ciloleucel) patient ambassador.

This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.


What’s important to know when considering YESCARTA?

Here are three special considerations that may be different from your experience with other cancer treatments. There may be other considerations depending on your situation. Ask your oncologist or treatment team for more information.

YESCARTA is only given at certified treatment centers?, also known as authorized treatment centers. These centers have medical staff who are specifically trained to take care of you throughout the whole CAR T-cell therapy process.

You can expect to stay at the certified treatment center for at least 1 week after infusion, and have multiple appointments before and after. Visit the Receiving YESCARTA page to learn more.

Your treatment team will let you know how close you need to stay to the treatment center for the first 4 weeks after infusion. If you don’t live nearby, you may need to travel, find lodging, and consider other costs.

Find and learn about a certified treatment center close to you:

YESCARTA may cause side effects that are life-threatening and can lead to death. Your treatment team at the certified treatment center will be working with you to closely monitor and manage side effects.

Some side effect symptoms can be hard for patients to recognize, and this is one of the reasons you will need a dedicated caregiver. If you don’t have a dedicated caregiver, you can work with your treatment team to come up with a solution.

Visit the Managing side effects page and Important Facts about YESCARTA to learn more.

Each step of treatment can take time to organize and prepare for. Talk to your treatment team about planning for CAR T.

“I read as much as I could, and listening to other patients’ stories was so valuable. Even though I was afraid, I knew I could do it. I was only the 13th person to have treatment after FDA approval.”

NikkiYESCARTA Patient

This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.

Nikki YESCARTA® (axicabtagene ciloleucel) patient ambassador.

This testimonial is representative of the patient’s own experience. Individual treatment results and experience may vary.

CAR T-cell therapy

CAR T-cell therapy, or CAR T for short, is a type of immunotherapy. In CAR T, your T cells are modified to recognize and attack certain cancer cells. This is done by modifying your T cells to have Chimeric Antigen Receptors (CARs). This turns them from T cells into CAR T cells.
A T cell modified to have CAR which then becomes a CAR T cell.

Chimeric Antigen Receptors

A Chimeric Antigen Receptor (CAR) is a special molecule designed to help T cells recognize and attack cancer cells.

CARs hook onto a specific marker that cancer cells have a lot of. These markers are called antigens. When CARs hook onto these antigens, it can cause T cells to respond.

With YESCARTA, the CARs hook onto CD19, which is found on cancerous and normal B cells.

A chimeric antigen receptor (CAR) hooking onto an antigen.

Certified treatment center locator tool

There are over 120 cancer centers certified to provide YESCARTA throughout the US. When choosing a location, consider that you will need to stay close to the center for at least 4 weeks after receiving YESCARTA.

You can use the locator tool to find and learn about nearby treatment centers and their teams.

Information on new centers (where available) will be added on an ongoing basis. You can also contact your treatment team to learn more.

Certified treatment centers (also called Authorized Treatment Centers) are independent facilities certified to dispense Kite CAR T therapies. Choice of a certified treatment center is within the sole discretion of the physician and patient. Kite does not endorse any individual treatment sites. Insurance coverage should be considered when reviewing certified treatment center options.


Patient and caregiver perspectives

This testimonial is representative of patients’ and caregivers’ own experiences. Individual treatment results and experience may vary.

What to know about CAR T

Learn about what was important to other patients and caregivers

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Have questions? Call us

Your treatment team is the best resource for support throughout treatment.

If you have questions at any step of the CAR T process, our dedicated team at Kite can also help. You can call them at:



If you have questions at any step of the CAR T process, our dedicated team at Kite can help.



Certified treatment centers

In order to provide YESCARTA, cancer treatment centers must first be certified. Certified treatment centers have specifically-trained medical staff, strict treatment protocols, and safety measures in place for CAR T-cell therapy. These centers are often first to use best care practices learned through research.

Certified treatment centers are sometimes known as authorized treatment centers.

Approved Uses

YESCARTA is a prescription medicine used to treat two types of non-Hodgkin lymphoma ...

Important Safety Information

What is the most important information I should know about YESCARTA? YESCARTA may cause side effects that are life-threatening and can lead to death ...

Approved Uses and Important Safety Information

Approved Uses

YESCARTA is a prescription medicine used to treat two types of non-Hodgkin lymphoma:

  • large B-cell lymphoma when your first treatment did not work or your cancer returned within a year of first treatment, OR when at least two kinds of treatment have failed to control your cancer.
  • follicular lymphoma when at least two kinds of treatment have failed to control your cancer.

YESCARTA is different than other cancer medicines because it is made from your own white blood cells, which have been modified to recognize and attack your lymphoma cells.

Important Safety Information

What is the most important information I should know about YESCARTA?

YESCARTA may cause side effects that are life-threatening and can lead to death. Call or see your healthcare provider or get emergency help right away if you get any of the following:

  • Fever (100.4°F/38°C or higher)
  • Difficulty breathing
  • Chills or shaking chills
  • Confusion
  • Dizziness or lightheadedness
  • Severe nausea, vomiting, or diarrhea
  • Fast or irregular heartbeat
  • Severe fatigue or weakness

It is important to tell your healthcare provider that you received YESCARTA and to show them your YESCARTA Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

Before getting YESCARTA, tell your healthcare provider about all your medical problems, including if you have or have had:

  • Neurologic problems (such as seizures, stroke, or memory loss)
  • Lung or breathing problems
  • Heart problems
  • Liver problems
  • Kidney problems
  • A recent or active infection

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive YESCARTA?

  • Since YESCARTA is made from your own white blood cells, your blood will be collected by a process called “leukapheresis” (loo-kah-fur-ee-sis), which will concentrate your white blood cells.
  • Your blood cells will be sent to a manufacturing center to make your YESCARTA.
  • Before you get YESCARTA, you will get 3 days of chemotherapy to prepare your body.
  • When your YESCARTA is ready, your healthcare provider will give it to you through a catheter placed into your vein (intravenous infusion). The infusion usually takes less than 30 minutes.
  • You will be monitored where you received your treatment daily for at least 7 days after the infusion.
  • You should plan to stay close to the location where you received your treatment for at least 4 weeks after getting YESCARTA. Your healthcare provider will help you with any side effects that may occur.
  • You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
  • Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

What should I avoid after receiving YESCARTA?

  • Do not drive, operate heavy machinery, or do other dangerous things for 8 weeks after you get YESCARTA because the treatment can cause sleepiness, confusion, weakness, and temporary memory and coordination problems.
  • Do not donate blood, organs, tissues, or cells for transplantation.

What are the possible or reasonably likely side effects of YESCARTA?

The most common side effects of YESCARTA include:

  • Fever (100.4°F/38°C or higher)
  • Low white blood cells (can occur with a fever)
  • Low red blood cells
  • Low blood pressure (dizziness or lightheadedness, headache, feeling tired, short of breath)
  • Fast heartbeat
  • Confusion
  • Difficulty speaking or slurred speech
  • Nausea
  • Diarrhea

These are not all the possible side effects of YESCARTA. Call your healthcare provider about any side effects that concern you. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see the Important Facts, including IMPORTANT WARNINGS.